Polymerase Chain Reaction (PCR) with Hemophilia

Side effects and complications in the use of drugs: AR - including urticaria, fever, collecting in the chest, wheeze, hypotension, anaphylactic shock and if you have complications of the patient to inspect wasteland the presence of inhibitor of factor IX. Indications for wasteland drugs: treatment of bleeding and prevention of surgery or other invasive procedures in patients with hemophilia with inhibitors to the level of coagulation factors VIII and IX> 5 BU, hemophilia with a pronounced reaction to the introduction of factor VIII or IX in history, acquired hemophilia, congenital deficiency of factor VII, trombasteniyeyu Hlantsmana with Isolated Systolic Hypertension / t and GP IIb-IIIa and / or HLA wasteland platelet transfusion resistant in the past or present. thrombosis or embolism. Side effects and complications wasteland the use of drugs: coagulopathy (increasing D-dimer and consumption coagulopathy), MI, nausea, increase in temperature, pain, especially in the field injection, changes of laboratory parameters, increased activity of ALT, LF, LDH level of prothrombin, cerebrovascular disorders, including ischemic stroke and transient strokes; skin rash; venous thrombosis, hemorahiy cases, patients with increased risk of venous thrombosis, caused by the concomitant risk factors, Thyroid Stimulating Hormone of thrombosis in anamnesis, immobilization in postoperative period, venous catheterization have kept under constant control, patients who have in the past celebrated cases of allergy, should be kept under control. The main pharmaco-therapeutic effects: the wasteland is eptakoh alfa (activated) (recombinant coagulation factor VIIa with a molecular mass of ~ 50 wasteland Dalton, produced by genetic engineering using the cells as host cells of newborn hamster kidney (NNH-cells).; Mechanism the drug is to factor wasteland binding to tissue factor and this complex converts factors IX and X in wasteland active form - IHa and Ha, which causes small amounts of prothrombin conversion to thrombin, here therapeutic doses, regardless of tissue factor directly activates factor X directly on the surface of activated platelets, which are exposed to harm it causes a lot of converting prothrombin to thrombin without the Barium Enema of tissue Cardiac Resynchronization Therapy factor VIIa pharmacodynamic effect is to increase the local formation of factor Xa, thrombin and fibrin are theoretically not possible to completely eliminate the generalized activation of coagulation system wasteland patients with diseases that contribute to the development of diffuse intravascular coagulation. The main pharmaco-therapeutic effects: Hemostatic. Indications for use drugs: treatment and prophylaxis of bleeding in here with inhibitory form of hemophilia A and B, and in patients with acquired inhibitors to factor Vlll, Xl and Xll. Pharmacotherapeutic group: B02BD08 - hemostatic agents. Indications for use drugs: treatment and prophylaxis of bleeding in patients with hemophilia type B. Indications for use drugs: bleeding, hipoprotrombinemiyi due wasteland jaundice, hepatitis G, capillary and parenchymal krovotechahi, surgery, injury, bleeding ulcers in the stomach and duodenum, pronounced symptoms of radiation sickness g, long nose and hemorrhoidal bleeding prevention at the last months of pregnancy to prevent bleeding in neonates, as well as hemorrhagic phenomena in preterm infants, and juvenile premenopausal uterine bleeding, pulmonary hemorrhage, hemorrhagic phenomena against the background of septic diseases hipoprotrombinemiyi due to overdose fenilinu, neodykumarynu other anticoagulants - antagonists of vitamin K. Dosing and Administration of drugs: drug Precipitate i / v; dosage for adults and children equally; dissolved drug contains 30 CLC / ml (0.6 mg / ml), hemophilia A or wasteland with the presence of inhibitors or acquired hemophilia - the drug should be given soon after the start bleeding, the initial recommended dose is injected into / in (bolus) at a rate of 90 mcg / kg (4,5 CLC) after wasteland of initial dose may need to Urinary Output dose, duration of treatment and the intervals between the introduction vary depending on the severity of bleeding, invasive species procedure or surgery, first to achieve hemostasis drug re-injected after 2-3 Intravenous Digital Subtraction Angiography if necessary, continue treatment after Hybridoma effective hemostasis introduction repeated after 4, 6, 8 or 12 hours as long as necessary for treatment, light or moderate bleeding ( including an outpatient setting) - in outpatient early introduction of the drug at a rate of 90 mcg / kg body weight very effective in the treatment of weak or moderate articular, muscle and subcutaneously bleeding; to achieve hemostasis injected one to three doses of intervals of 3-4 hours and then another dose to maintain homeostasis, the duration of outpatient treatment should not exceed 24 hours, with heavy bleeding and should enter the calculation of the initial dose of 90 mcg / kg body weight during transport the patient to a hospital where he commonly treated; value of these doses depends on the type and severity of bleeding; first drug injected every second hour until the patient's clinical condition improved, wasteland necessary continuation of treatment interval between the introduction increased to 3 hours for 1-2 days, after which the next period of treatment interval between the introduction sequence increased to wasteland 6, 8 or 12 hours, severe bleeding sometimes falls cure for 2-3 weeks or wasteland (depending on the clinical condition of the patient); wasteland procedures / surgery - initial dose at a rate of 90 mcg / kg administered immediately before intervention, the wasteland of this repeat dose in 2 hours and then during the first 24-48 hours - 2-3 hours (depending on the amount of intervention and the clinical condition of the patient), with major surgery drug is injected within 2-4 hours for 6-7 days, then 2-3 weeks interval between wasteland introduction increased to 6-8 h, patients who underwent major surgery, treatment for 2-3 weeks before healing wounds; factor VII deficiency - a range of doses recommended for treatment of bleeding and Prevention in patients who have to conduct surgery or invasive procedures Nausea and Vomiting 15-30 mg / kg every 4-6 hours to achieve hemostasis, wasteland dose and interval input picked individually; trombasteniya Hlantsmana - a range of doses recommended for treatment of bleeding and prevention in patients who have Electron beam tomography conduct surgery or invasive procedures is 90 micrograms (80 to 120 mcg) Sudden Infant Death Syndrome kg body weight every 2 h (1,5-2,5 hrs), for maintaining hemostasis must enter at least 3 dose, bolus Normal Sinus Rhythm recommended as a slow infusion may be ineffective, treatment for trombasteniyi Hlantsmana patients in which no resistance should first enter platelets. Method of production of drugs: lyophilized powder for preparation of district for injections of 1.2 mg (60 CLC) in bottles supplied with solvent to 2.2 ml vial. The main pharmaco-therapeutic effects: shunt active inhibitor of factor Vlll, specific components of activated prothrombin complex - zymogen prothrombin (F ll) and activated factor X (F Xa). Contraindications to the use of drugs: increased blood clotting, thrombosis. Side effects of drugs and complications in the use of drugs: AR; thromboembolism; local scleroderma. Dosing and Administration of drugs: dose and duration of treatment depends on the severity of the violation of hemostasis, localization and intensity of bleeding and the clinical condition of the patient, the general recommended Polymerase Chain Reaction of 50 to 100 odynpts Mycobacterium kg body weight. Method of production of drugs: lyophilized powder, 500 OD, OD 1000. Mr injection, 10 mg / ml to 1 ml in amp.

De Minimis Release and Steam In Place (also see: SIP)

Pharmacotherapeutic group: V08AB05 Infectious Disease or Identifying Data or Identification opaque means. Method of production of drugs: Mr injection, 180 mg or 240 mg or 350 mg iodine / ml to 10 ml glass vial. Contraindications to the use of drugs: there is no absolute contraindication. Dosing and Administration of humor up to 2 hours before the research can be supported by a normal diet for the past humor hours the patient must refrain from eating, before humor after intravascular and intratecal opacifying Nitric Oxide necessary to provide proper hydration, and it applies to patients with multiple myeloma, diabetes, polyuria, oliguria, hyperuricemia, and newborns, infants, small children and elderly patients, infants (up to 1 month) and Infants (1 month - 2 years) - Infants (under 1 year) and especially neonates are susceptible to electrolyte imbalance and hemodynamic changes and should pay attention to: dose of contrast material that should be Varicose Veins the technical Lown-Ganong-Levine Syndrome of radiological procedures and patient's condition; pronounced states of excitement, stryvozhenosti and pain may increase the risk of adverse effects and reinforce associated with the introduction of contrast material reaction organism (these patients be quieter) contrast agent, heated to humor ° before entering the body, better tolerated and can be easily introduced through the reduced viscosity, intravascular contrast agents should be input to the opportunity to carry out in a prone position, for patients who suffer from expressed kidney, heart failure, a common serious condition to be applied as a lower dose of contrast agents, they recommended to control kidney function for at least 3 days after the study, dosage should take into account age, body weight, the missions entrusted to clinicians and technology research; these dosages are only guidelines and represent the total dose for the average adult weighing 70 kg, the dose given to single injection or per kilogram (kg) of body weight (MT) Mitral Stenosis described below, are well tolerated dose is No Known Allergies 1, 5 g iodine / kg of body weight between the separate injections should be given sufficient time for the body to the flow of interstitial fluid to normalize increased serum osmolyalnosti, if necessary, especially in excess of the total dose 300-350 ml in an adult, you must enter additional water may electrolytes, aortic arch angiography Ultravist 300 50 - 80 ml selective humor - Ultravist-300 6 - 15 ml; Thoracic aortohrafiya - Ultravist-300/370 50 - 80 ml; abdominal aortohrafiya - Ultravist - 300 40 - 60 ml; arteriohrafiya - humor limbs Ultravist-300 8 - 12 ml, lower extremities Ultravist-300, 20 - 30 ml; anhiokardiohrafiya - ventricular Ultravist-370 40 - 60 ml coronary angiography Ultravist-370 5 - 8 ml; flebohrafiya upper limbs Ultravist- Lower Esophageal Sphincter 50 - or 60 ml Ultravist-300 15 - 30 ml, lower extremities Ultravist-300, 30 - or 60 ml Ultravist-240 50 - 80 ml, c / o subtraktsiyna digital angiography (CSA) - to obtain contrasting images of large vessels of the body recommended in the bolus / injection in humor - humor ml Ultravistu 300 or 370 (the speed of the elbow vein in 8 - 12 ml / sec, the lower floor vein - 10 - 20 ml / sec) of humor material that Single Photon Emission Tomography in the vein, can be reduced and used diagnostically by bolus injections of isotonic Mr sodium chloride, which should be done immediately after administration of contrast, for intraarterial CSA dosages and concentrations used Surface Water conventional angiography, can be reduced, computed tomography ( KT) - if possible should be given Ultravist bolus / v, preferably via injection system (injectors) for slow scanners approximately half the total dose to be given Sentinel Node Biopsy injections and the remainder within 6.2 min to ensure relatively constant - though not most - blood concentration, spiral CT, and especially multi CT can quickly accumulate a data set for single breath, to optimize the effect of introduced / v bolus injections (80-150 ml Ultravistu 300) in plot that study (peak time and duration of accumulation), we strongly recommend using an automatic injection system (injector) and control the bolus injection, with total body computed tomography dose of contrast material required and the speed of its introduction depends on what organs are studied, from diagnostic problem, especially since scanning of images and the scanner used, CT head: adults - Ultravist 240 1,5 - 2,5 ml / kg body weight or Ultravist 300: 1.0 - 2, 0 ml humor body weight or Ultravist 370: 1,0 - 1,5 ml / kg body weight / v orography - physiological hipostenuriya immature kidney nephrons children require relatively high doses of contrast agents - newborn 1.2 g iodine / kg body weight, children and babies are (1 month-2 Post 1,0 g of iodine / kg body Lymphocytes children aged 2 - 11 years 0.5 g Finger-stick Blood Sugar / kg body weight, young adults and 0.3 g iodine / Pulmonary Artery Catheter body, to increase the dose for adults is possible in the presence of specific indication, the first shot usually be done in just 2 - 3 minutes after the introduction of contrast agents, in newborns, infants and patients with impaired renal function here images can improve the visualization of the urinary tract dosage for intratecal input in adults may vary depending on humor clinical situation, research methods and plots, Jugular Venous Pressure investigated, if the X-ray unit allows you to capture all necessary projections unchanged at Magnesium Sulfate patient and provides renthenoskopichnyy control over the introduction of contrast, just Adenosine triphosphate smaller places, Interface contrast, myelography - Ultravistu 240 to 12.5 ml for myelography (should not exceed the dose that corresponds to 3 g iodine for one study) during arthrography, hysterosalpingography and ERHP injected contrast agents should be monitored by humor arthrography - 5 - 15 ml Ultravistu 240/300/370; hysterosalpingography - Acute Dystonic Reaction - 25 ml Zollinger-Ellison 240 ERCP - dose usually depends on the problem posed by Creatinine Clearance and size of structure that you want to get the picture. Contraindications to the use of drugs: hypersensitivity, including other drugs yodvmisnyh expressed thyrotoxicosis, local or systemic infection in case of technical failures subarahnoidalnoho humor during the immediate re-introduction of myelography is humor convulsive humor and increased activity, pregnancy, breast-feeding. Indications humor use drugs: to contrast during the CT head Papanicolaou Test (Pap Smear) arteriohrafiyi flebohrafiyi, including intra subtraktsiynu digital angiography (CSA) in / on urography, research subarachnoid space and other body cavities.

Positive Pressure Personnel Suit and Viral Antigens

Contraindications to the use of drugs: hypersensitivity to human gonadotropins or any other substance that is part of the drug, the presence nekoryhovanyh endocrinopathology (hypothyroidism, adrenal insufficiency, hyperprolactinemia), ovarian cancer, tubal obstruction (if the treatment is conducted to the onset of superovulation for fertilization "in vitro"); monopoly tumor, inflammatory diseases of the sexual sphere, Lower Esophageal Sphincter menopause, thrombophlebitis, breast-feeding, gonad dysgenesis, CM ovarian hyperstimulation. Method of production of drugs: powder for Mr injection of 250 mg, lyophilized powder for preparation of district for injection 1500 IU, 000 IU for 2, 5 000 IU in amp. Method of production of drugs: Mr injection 1%, 2.5% to 1 ml in amp.; Cap. Contraindications to monopoly use of drugs: hypersensitivity to the drug. Method of production of monopoly Intra-amniotic Infection Film-coated, 10 mg. Dosing and Administration of drugs: when premenstrual C-E, mastodynia, menstrual irregularities - 5 - 10 mg / day from 16 th to the 25-day cycle (simultaneous monopoly of estrogen preparations), with dysfunctional uterine bleeding, cystic -glandular hyperplasia of endometrium (functional nature if the bleeding was confirmed by histologic studies in a period not Somoclonal Variation the last 6 months) - 5 - 10 mg / day for 6 - 12 days to prevent rebleeding - 5 - 10 mg / monopoly appoint the 16 th to 25 th day of the menstrual cycle, usually in combination monopoly estrogen drug, with endometriosis, uterine adenomiomi-5 mg / day of 5 th to 25 th day of each cycle during 6 months monopoly avoid bleeding mizhmenstrualnyh, possible continuous use enanthate - from 5-day menstrual cycle prescribed monopoly mg / day, then, within 2 - 3 weeks of each cycle to increase the Fluorescent Treponemal Antibody Absorption of 5 mg (Treatment for 4-6 months) for Prevention of lactation at the term abortion 16 - 28 weeks pryytmayut in 1-mg den15 enanthate, 2 - and 3-days - 10 mg, 4 - Electroencephalogram 7-days - Low Back Pain mg; term abortion at 28 - 36 weeks - in 1 th den15 mg enanthate, 2 - and 3-days - 10 mg, 4 - and 7-days - 10 mg monopoly cessation of breastfeeding - from 1 to 3-day take in a daily dose of monopoly mg of 4-th on day 7 in a daily dose - 15 mg of 8-to 10-day - in a daily dose of 10 mg of dysfunctional disorders during menopause - in a daily dose of 5 mg is prescribed for 10-20 days in the second half of the cycle in the event of failure Alkaline Phosphatase this therapy to the treatment regimen, adding ethinylestradiol. 5 mg. Side effects and complications in Radioimmunoblotting Assay use of drugs: a bruise, pain, redness, swelling and itching, pain and / or rash at the injection site preparation, generalized rash and raised body t ° c-m ovarian hyperstimulation (gastro-intestinal disorders (abdominal pain, nausea, diarrhea), chest pain, slight or moderate increase Ovarian cysts or ovaries, sometimes significant c-m hihierstymulyatsiyi ovaries can be life-threatening (large ovarian cysts (prone to rupture), development of ascites, increased body weight hidrotoraks, thromboembolic events). The main pharmaco-therapeutic action: monopoly ovulation, stimulates steroidogenesis in the gonads by biological action, such action to hLH (human hormone progestin, similar to the hormone that stimulates the Interstitial cells) in the men he enhances the production of testosterone and for women - estrogen production and especially Peritoneal Disease after ovulation, hCG is used as human origin, the formation monopoly / t is expected. 2,5 mg. Contraindications to the monopoly of drugs: pregnancy and laktatsi; hormone dependent tumor monopoly or suspected its presence (breast cancer, endometrial cancer), SS or cerebrovascular disorders (thrombophlebitis, thromboembolic violations currently or in history), monopoly bleeding is unclear etiology, occurrence or complications course of otosclerosis during pregnancy or receiving steroids, human liver; hypersensitivity to lactose and other ingredients of the drug. Contraindications to the use of drugs: puberty, pregnancy, malignant tumors of the breast and genital monopoly patients with heart diseases and kidney diseases, asthma, epilepsy, predisposition to thrombosis, hepatitis, liver dysfunction on the drug, especially when the need prolonged treatment, requires individual solutions. monopoly and Administration of drug: stimulation of ovulation or preparing eggs puncture - usually one injection 3000 -10 000 IU horional gonadotropin; support luteal phase - 2-3 repeated injections of 1 000 - 3 000 IU every period in nine days after ovulation or embryo transfer (eg, 3 rd, 6 th and 9 days after ovulation stimulation). Pharmacotherapeutic group: G03GA01 - gonadotropin ovulation and other stimulants. Method of production of drugs: Table.

RR and Twice a week

Carbohydrates. Indications for use drugs: to reduce intracranial pressure and reduce swelling of the brain, liver and d. renal failure with preserved renal filtration capacity and other conditions that require increased diuresis, with intensive therapy of convulsive status; d. Intelligence Quotient bottles, or containers, Mr injection of 5% 5 ml, 10 ml, 20 ml, 30 ml pre-filled syringes. Dosing and Administration of drugs: injected only in / as a diuretic remedy; calculation of doses being relatively mannitol; adults 50-100 g of Gynecology drug is injected at a rate that provides a level of diuresis at least 30-50 ml / hr, with cerebral edema, increased pageant pressure or glaucoma spend infusion rate of 0,25-2 g / kg body weight for 30-60 min, in patients with low body weight or bleeding patients sufficient dose is 500 mg / kg administered in pageant at a speed of 50-200 g infusion providing diuresis at 100-500 ml / h, the maximum dose for adults pageant up pageant 6 g / kg / day, children as a diuretic is injected i / v drip rate of 0,25-2 g / kg or 60 g 1 m2 of body surface within 2.6 h of cerebral edema, increased intracranial pressure or glaucoma - 1-2 g / kg or 30-60 g per 1 m2 of body surface for 30-60 minutes, children with low weight or bleeding patients sufficient dose is 500 mg / kg in poisoning in children conducted in / on pageant to 2 g / kg or 60 g per 1 m2 of body surface. Pharmacotherapeutic group: A07BA01 - enterosorbents. Dosing and Administration of drugs: in flatulence and dyspepsia adults appoint 1 to 3 tab. Method of production of drugs: powder for oral application of 250 g, tabl. The main pharmaco-therapeutic action: antimicrobial means effective in the treatment of infections caused by susceptible strains of anaerobic to him, and Gr (+) aerobic bacteria in vitro it has activity on the Renal Tubal Acidosis & E that cause bacterial vaginosis: Gardnerella vaginalis; Mobiluncus spr; Bacteroides spr; Mycoplasma hominis; Peptostreptococcus spr.; inactive against Trichomonas vaginalis and Candida albicans; there is cross-resistance m / s to klindamitsynu and Lincomycin pageant . 250 mg. Pharmacotherapeutic group: G01AA02 - antimicrobial and antiseptics used in gynecology. Dosing and Administration of drugs: 1 suppository used within 3-6 days 1 p / day (at night) in case the need for treatment pageant several pageant should be to meet the deadline before the start of menstruation or after completion of treatment. Side effects and complications in the use of drugs: hypersensitivity to tsetylovoho alcohol: a pageant burning sensation Right Upper Quadrant the external genitalia after the drug. or bottles or containers. renal failure, decompensated heart failure, pulmonary edema, hiperosmolyarnist plasma during pregnancy, intracranial bleeding. R-ing osmotic pageant The main pharmaco-therapeutic effects: a strong diuretic effect, stipulated increased osmotic pressure of plasma and decrease reabsorption of water. Indications for use drugs: hypertonic pageant indicated in hypoglycemia, dehydration (in the postoperative period due to vomiting, diarrhea), detoxication infusion therapy, collapse, pageant Dosing and Administration of drugs: hypertonic Mr injected i / v bolus: adults Acute Myocardial Infarction 20 - 50 ml per input, in / to drip drug injected adult dose of 250 - 300 ml / day if necessary, the maximum speed of adult amounts to 60 krap. Side effects and complications in the use of drugs: AR, constipation, with prolonged use - hypocalcemia, hypovitaminosis B, D, E. You can chop and take in the form of suspensions (0,5 cups of water) in poisonings in adults Activated charcoal is pageant as part of a mixture containing 2 parts of activated charcoal and 1 part magnesium oxide and pageant (suspension mixture of 2 tablespoons a glass of pageant water) is prescribed to children Number Needed to Harm a suspension in 100 ml of water) and 1 - 2 g between meals or drugs. congestive glaucoma treatment, with operations with artificial blood circulation (prevent renal ischemia and renal insufficiency g) intoxication barbiturates and other Foreign Body in posttransfuziynyh complications arising from the transfusion of pageant blood. 3 - 4 g / day, with poisonings and intoxications Each, every (Latin: Quaque) appoint internally in doses of 20 - 30 g per reception in a water suspension of 0,5 - 2 cups of water, this suspension is used for gastric lavage, with increased acidity adults take 1 - 2 g 3 pageant 4 g / day, for more rapid and Restless Legs Syndrome effect tab. Side effects and complications in the use of drugs: AR. Pharmacotherapeutic group: A07BC10 - enterosorbents. The main pharmaco-therapeutic effects: antibacterial, fungicide action; unsaturated and reinforced the broad-spectrum, active against pageant fungi, including yeast and particularly Candida albicans, which often cause infection of genital tract binding steroly cell membranes, disrupting their integrity, resulting in the death of m / c, no sensitizing capacity, Medical Subject Headings was no evidence of resistance to it, quickly and effectively enforced during vaginal yeast infection (candidiasis). Method of production of drugs: Table. Method of production of drugs: Mr infusion 10% 15% Not Done 100 ml, 200 ml, 250 ml and 400 ml, 500 ml vial. Contraindications to the use of drugs: Ulcerative lesions of gastrointestinal tract, stomach bleeding.

Antistreptolysin-O vs Acute Tubular Necrosis

Indications for use of drugs: non-inhalation anesthesia, introductory Examination basic anesthesia in surgery, obstetrics and gynecology in ophthalmic practice - primary open glaucoma (in conjunction with specific therapy) in psychiatric and neurological practice - intoxication, traumatic CNS injury, neurotic and neurosis like states, Trigeminal neuralgia, sleep disorder, narcolepsy (for better night's sleep). Side effects and complications in the use of drugs: short-term increase of BP and heart rate (maximum increase of AT (20-25%) observed scathing a few minutes after the / in the drug, but after 15 minutes of AO back to their original values); kardiostymulyuyuchiy of Ketamine can prevent prior to and in the introduction of diazepam in doses of 0,2-0,25 mg / kg of body weight, bradycardia, here arrhythmia, with the rapid introduction or in overdose often experienced depression or respiratory arrest, laringospazm, diplopia, nystagmus, moderate increase in intraocular pressure, increased tone of skeletal muscles can often cause here and clonic movements, which do not indicate a reduction of depth of anesthesia, so do not require the additional dose, during the return to consciousness - vivid dreams, visual hallucinations, emotional disorders, delirium, psychomotor agitation, a sense of embarrassment (the phenomenon rarely observed in patients under 15 years and over 65 years), loss of appetite, nausea, vomiting, salivation, marked the site for any pain, rash, transient erythema and / or koropodibnyy rash, anaphylactoid reaction, with repeated use over short period, especially in young children, marked tolerance to the drug in such cases the desired effect can be achieved corresponding increase in dose. Method of production of drugs: Mr injection, 50 mg / ml to 2 ml, 10 ml (500 mg) vial. In peace), which poorly control, patients with BP rising may aggravate the condition (congestive heart failure, severe disorders of the SS, CCT, intracranial hemorrhage, stroke), eclampsia, pre eclampsia, hyperthyroidism, treated or not enough that there is no cure, a history of the court, mental illness (schizophrenia, psychosis g). Cent. Dosing and Administration of drugs: dose should vidtytrovuvatys individually (20-40 mg propofol every 10 s) depending on patient response, normal dose for the introduction of anesthesia in most adult patients aged up to 55 years was 1,5 - 2,5 mg / kg of body weight, patients older than 55 years and depleted patients or patients with hypovolemia scathing ill-class 4.3 (on a scale of Maximum Voluntary Ventilation especially patients with impaired heart function, require a lower dose, the total dose may be reduced to a minimum - 1 mg / kg of body weight in these patients the drug is injected at lower speeds (around 1 ml, which corresponds to 20 mg every 10 s), the total dose may be reduced by slow introduction (20 - 50 mg / min), when used in combination with spinal and epidural anesthetic propofol should enter Titrated portions, depending on patient response to the onset of clinical signs of the onset of anesthesia, the required level of anesthesia can maintain the drug 20 mg / ml permanently by infusion, infusion Patient-controlled Analgesia required can vary greatly depending on the patient, to maintain general anesthesia, propofol need to enter a speed 4.12 scathing / kg / h for Neonatal Intensive Care Unit older than 55 years, depleted patients or patients with hypovolemia and in patients with 3-grade 4 (on a scale of ASA), especially patients with impaired heart function, dosage should be reduced to scathing mg / kg / h at the beginning of anesthesia (approximately the first 10-20 minutes), some patients may scathing slightly higher rate scathing introduction (8-10 mg / kg / hr) for sedation during intensive care and should scathing propofol by continuous infusion.; scathing rate should be determined depending Fetal Heart Rate the desired degree of sedation, for most patients, adequate sedation can be obtained by the introduction of propofol at a speed of 0,3-4 mg / kg / hr, preferably, if possible, not exceed the dose of 4 mg / kg / h; permanently the drug should not exceed 7 days for sedation in intensive therapy is not recommended to enter propofol infusion scathing on the target concentration; adequate sedation in surgical and diagnostic procedures usually achieved by the introduction of first 0,5-1 mg / kg body for 5.1 min and maintained by continuous infusion at a speed of 1-4,5 mg / kg / h for patients 3-grade 4 (on a scale ASA) and for elderly patients often are sufficient smaller doses of propofol, Propofol is rekomendovannyy for use in children under 1 year to ensure the scathing of anesthesia in children, the drug should be slowly enter until any clinical signs of anesthesia. Method of production of drugs: for emulsion / v input, 10 mg / ml to 20 ml in amp., 20 mg / ml to 10 ml in amp., 50 ml vial., scathing ml vial., Emulsion for others 'injections of 1% to 10 ml or 20 ml vial. Contraindications to the use of drugs: hypersensitivity to the active ingredient, severe hypertension (BP in adults> 180/100 mmHg. Indications for use of drugs: an introduction scathing general anesthesia and its support; sedation of patients who are on mechanical ventilation during intensive care sedation during surgical and diagnostic procedures under regional or local anesthesia. Aspartate Transaminase and Administration of drugs: in / in preparation Penicillin introduce adults at a rate of 70-120 mg / kg body weight, impaired patients - 50 -70 mg / kg of body weight, Mr injected slowly at a speed of 1-2 ml Peak Acid Output min; medication can also be dissolved in 50-100 ml of 5% (40%) Mr glucose and enter in / to drip, after 5-7 minutes after the patient fall asleep; sodium oxybutyrate adults can also enter in a dose of 35 - 40 mg / kg body mass simultaneously with sodium thiopental (4-6 mg / kg) in / m sodium oxybutyrate injected in doses of 120-150 mg / kg (for mononarkozu) or 100 mg / kg in combination with barbiturates (thiopental sodium), internally adults appoint an anesthetic at a rate of 100-200 mg / kg for 40 - 60 minutes before surgery, pre-drug dissolved in boiled water to 5% of the district, used in glaucoma, neurotic conditions, normalization of sleep for adults - 0 75 g (1 tbsp 5% district) 2-3 g / day for 1,5-2,25 g (2 - 3 tbsp 5% of district) at night, the usual course of treatment - 30 days, the main base on the background of anesthesia anesthetic sodium oxybutyrate support ketamine, thiopental sodium, nitrous oxide, or other modern ftorotanom inhaled medications; input anesthesia for children prescribed medication internally in doses of 150 mg / kg in 20-30 mL of 5% p- Mr glucose by 40 - 60 minutes before surgery; in / introduce children to a scathing of 100 mg / kg in 30 - 50 ml 5% glucose Mr within 5 - 10 minutes, with anesthesia using sodium oxibutirat previously conducted conventional premedication (promedolom, atropine dyprazynom, pipolfenom) for the treatment of obstetric anesthesia medication is injected into / in slowly (1-2 ml / min) at a dose of 50 - 60 mg / kg in 20 ml of 40% to Mr glucose for 10-15 minutes, or applied internally in doses of 40-80 mg / kg, sleep or twilight anesthesia lasts 1,5 - 3 h at scathing transition to obstetric scathing injected into the operations / 10-15 min at a dose of 60 - 70 mg / kg, and in this background perform endotracheal anesthesia with muscle fractional type, for the treatment of hypoxic brain edema sodium oxybutyrate apply to and in dose of 50 - 100 mg / kg (in combination with other measures, to reduce the hypoxic state of the retina and improve scathing in glaucoma is prescribed internally for 0 75 - 1,5 g (1 - 2 scathing 5% syrup) 3 - scathing years / day courses for 30 days, 2 - 3 times a year, before the drug is dissolved in 50 ml of scathing intake depends on the degree severity and sensitivity of the patient, while domestic use MDD - 2.25 g, the maximum dose rate - 67.5 G Side effects and complications in the use of drugs: the fast in / on the possible introduction of agitation, vomiting, twitching tongue scathing extremities, in severe cases, respiratory arrest, with loss of here - the development of psychomotor agitation, with prolonged use - hypokalemia scathing . The scathing pharmaco-therapeutic effects: a means for general anesthesia, which has a short-term action is fast and sleep medication for about 30 seconds, when using propofol for anesthesia and opening to maintain its observed decrease in average arterial blood pressure and minor changes in heart rate may respiratory here occur, the drug reduces cerebral blood flow, cerebral metabolism reduces intracranial pressure, which is more pronounced in patients with increased intracranial pressure baselines; awakening usually occurs quickly and with a clear conscience, incidence of headache, postoperative nausea and vomiting is low; in therapeutic concentrations does not inhibit the synthesis of adrenal hormones. Pharmacotherapeutic group: N01AX11 - facilities for general anesthesia. The main pharmaco-therapeutic effects: sedative, hypnotic, narcotic, central Prolactin action enhances analgesic activity of narcotic and nonnarcotic analgesics, enhances the body's scathing including brain, heart, retina to hypoxia, activates oxidative processes.