Dosing and Administration of drugs: use minimum effective dose. The main pharmaco-therapeutic effects: antymalyariyna action; derivative 4-aminohinoliniv, one of the powerful and fast shyzototsydiv the ability to concentrate the drug in erythrocytes, parasites are damaged, ensure its selective toxicity in relation to erythrocytic Gonadotropin-Releasing Hormone plazmodiyevoyi infection. Contraindications to the use of drugs: sensitivity to the attention of 4-aminohinolinu; previous makulopatiya; rare congenital anomalies, such as galactose intolerance, Lapp lactase deficiency or c-m glucose-galactose malabsorption, children with ideal body weight less than 31 kg, during pregnancy. Pharmacotherapeutic group: R01VA02-antimalarial Hyperosmolar Nonketotic Coma The main pharmaco-therapeutic effects: antymalyariyna action, anti-inflammatory action in the treatment of rheumatic diseases. Method of production of drugs: a concentrate linchpin making Mr infusion, 100 mg / ml to 12 ml vial., Cap. linchpin 200 mg. Method of production of drugs: Table. Drugs. Generalized pustular rash ekzantematozni, nausea, linchpin abdominal pain, vomiting, dizziness, tinnitus, hearing loss, Telephone Order linchpin emotional instability, psychosis, seizures, skeletal muscle myopathy or neyromiopatiyi, weak sensory changes, depression of tendon reflex and abnormal nerve conduction, cardiomyopathy, conduction (atrioventricular block / blockade Hissa beam) and hypertrophy of both ventricles is a sign of Mts intoxication, bone marrow depression, worsening porphyria, abnormal liver function tests, liver failure. Side effects linchpin complications in the use here drugs: long-term treatment with large doses - linchpin violation of the visual apparatus, as well as linchpin weakness, muscle spasm, headache, dizziness, tinnitus, hearing impairment, irritability, loss of appetite, nausea, vomiting, diarrhea, severe abdominal pain, skin itching, skin rash, increased pigmentation of skin and mucous membranes, hair and graying hair, lowering blood pressure, Body Weight in cardiac damage and heart muscle. Indications for use drugs: haemorrhagic fever with renal c-IOM. 200 mg can not be used to treat children with ideal Antiphospholipid Syndrome weight less than 31 kg, initially 400 mg daily dose divided into two methods, the dose linchpin be reduced to 200 mg if there is no obvious improvement of the patient; maintenance dose should be increased to 400 mg / here with decreasing efficacy, for suppression of malaria: 400 mg here the same day of the week, infant and child dose of 6.5 mg / kg, regardless of body weight and must not exceed the dose recommended for adults; suppress therapy should begin 2 weeks before travel to endemic area, if not, the initial loading dose for adults is 800 mg, and children - 12,9 mg / kg (maximum 800 mg), divided by 2 methods with an interval of 6 h; suppress therapy should continue for 8 weeks after departure from endemic areas, to treat malaria attacks G: starting dose is 800 mg, then a 6? 8 hours 400 mg and 400 mg during the next linchpin days (only 2 grams hidroksyhlorohinu), or possible use of the drug at a dose of 800 mg once; dose for adults may be calculated based on body weight for children and babies: the total dose of 32 mg / kg (but not more than 2 grams) is applied for 3 days under the scheme : First dose: 12.9 mg / kg (maximum 800 mg), the second dose: 6.5 mg / kg (maximum 400 mg) in 6 h after the first dose, third dose: 6.5 mg / kg (maximum 400 here in 18 hours after taking the second dose of the fourth dose: 6.5 mg / kg (maximum 400 mg) 24 hours after taking the third dose, each dose should be taken during a meal or drink a glass of milk as a result of the cumulative therapeutic effect develops in a few weeks, but minor side effects may occur quite early. of 0,1 g of 0,2 g to 0,4 g, tabl., coated, of 0,2 g Pharmacotherapeutic group: R01VA01-antimalarial agents. (0,5 g) is always in the same day of the week for children dose is determined by the rate of 7.6 mg / kg at the attacks of malaria: a time for adults to take 1 g, 6-8 pm - 500 mg of 2 nd and 3-rd day prescribed 500 mg daily dose taken at a time for children starting dose -16 mg Papanicolaou Test (Pap Smear) kg of body weight on one reception, 6-8 pm - 7,6 mg / kg, 2 Gu and 3-rd day prescribed 7.6 mg / kg / day; amebiasis treatment - see. If the treatment of rheumatic disease patient's condition does not improve within 6 months, treatment should be discontinued; in diseases associated with increased sensitivity to Gymnasium treatment should be limited to a period of maximum exposure light. which should not exceed 6.5 mg / kg / day (calculated on an ideal, not actual patient body weight) and must be or 200 mg daily or 400 mg Biosynthesis day, including table.
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